247 The role of CXCL14 in melanoma progression and therapy resistance

Melanoma causes a majority of skin cancer related deaths even though it represents small fraction cancers. Remarkable advances in melanoma therapies are still unable to overcome therapy resistance. CXCL14, known chemokine for the chemotaxis and differentiation certain immune cells defense against bacterial infection, plays dual role It suppresses oral carcinomas, head neck cancers, lung whereas promotes breast prostate The antitumor effects CXCL14 based on fostered proapoptotic gene expression profile recruitment cells. Protumor caused by derived from associated fibroblasts (CAFs), which get stimulated an autocrine manner consecutively promote epithelial-to-mesenchymal transition, tumor cell growth, migration remains unknown. has been reported that patients suffering with high had worse overall survival rates, suggesting CXCL14’s protumor melanoma. We aimed check progression Using publicly available single-cell RNA sequencing dataset clinical samples, we found CAFs as main source CXCL14. further analysed genes whose mRNA levels were correlated those By employing enrichment functional annotation analysis, these mainly involved hallmarks resistance cancers: extracellular matrix organization (LOXL1, SFRP2, COMP), adhesion (MMRN1&2, THY1, PECAM1) angiogenesis (TEK, TIE1, S1PR1). Our computational findings indicate working checking how worsens possibly modulating immunity.